Dr. Brian S. McKay received his Bachelor’s degree in biology from University of Wisconsin in Milwaukee then completed his PhD at the Medical College of Wisconsin where he studied cell biology related to retinal diseases. Dr. McKay conducted his postdoctoral training in protein chemistry at The Scripps Research Institute in San Diego, CA. Upon finishing his training, Dr. McKay joined the faculty at Duke University in Durham, NC, where he developed his laboratory around projects addressing the biology of age-related macular degeneration (AMD). Dr. McKay conducts basic research towards understanding retinal degenerations and the molecular origins of glaucoma, asking the key questions necessary for successful development of cell based therapies. His collaborations with the vitreoretinal surgical staff are central to the projects success. Research is conducted in RPE transplantation methods for AMD therapy, and protein expression in glaucoma. In collaboration with W. Daniel Stamer, PhD, he is examining the structure and function of the myocilin to determine why the specific trait of glaucomatous disease is passed on through a nearly ubiquitous protein.
Brian S. McKay, PhD
|Professor, Ophthalmology and Vision Science|
PhD, Medical College of Wisconsin, 1995
Figueroa, A. G., and B. S. McKay, "GPR143 signaling and retinal degeneration", Advances in Experimental Medicine and Biology: Springer Publications, In Press.
Nguyen, T-V. V., M. Hayes, J. C. Zbesko, J. B. Frye, N. R. Congrove, N. P. Belichenko, B. S. McKay, F. M. Longo, and K. P. Doyle, "Alzheimer's associated amyloid and tau deposition co-localizes with a homeostatic myelin repair pathway in two mouse models of post-stroke mixed dementia.", Acta Neuropathol Commun, vol. 6, issue 1, pp. 100, 2018 Sep 24. PMCID: PMC6154927 PMID: 30249297
McKay, B. S., R. R. Allingham, and W. D. Stamer, "Is there a final common pathway in POAG?", Glaucoma Research and Clinical Advances: 2018 to 2020 - Google Books [Internet]: Kugler Publications, pp. 99-110, 2018.
Chung, A. G., J. B. Frye, J. C. Zbesko, E. Constantopoulos, M. Hayes, A. G. Figueroa, D. A. Becktel, A. W Day, J. P. Konhilas, B. S. McKay, et al., "Liquefaction of the Brain following Stroke Shares a Similar Molecular and Morphological Profile with Atherosclerosis and Mediates Secondary Neurodegeneration in an Osteopontin-Dependent Mechanism.", eNeuro, vol. 5, issue 5, 2018 Sep-Oct. PMCID: PMC6223114 PMID: 30417081
McKay, B. S., and S. G. Schwartz, "Pigmentation and macular degeneration: is there a role for GPR143?", J Ocul Pharmacol Ther, vol. 32, issue 1, pp. 3-4, 2016 Jan-Feb.
Brilliant, M. H., K. Vaziri, T. B. Connor, S. G. Schwartz, J. J. Carroll, C. A. McCarty, S. J. Schrodi, S. J. Hebbring, K. S. Kishor, H. W. Flynn, et al., "Mining retrospective data for virtual prospective drug repurposing: L-DOPA and age-related macular degeneration.", Am J Med, vol. 129, issue 3, pp. 292-8, 2016 Mar. PMCID: PMC4841631 PMID: 26524704
C Summers, G., J. E. Connett, A. M. Holleschau, J. L. Anderson, I. De Becker, B. S. McKay, and M. H. Brilliant, "Does levodopa improve vision in albinism? Results of a randomized, controlled clinical trial.", Clin Exp Ophthalmol, vol. 42, issue 8, pp. 713-21, 2014 Nov. PMCID: PMC4169362 PMID: 24641678
Locke, C. J., N. R. Congrove, M. W Dismuke, T. J. Bowen, D. W Stamer, and B. S. McKay, "Controlled exosome release from the retinal pigment epithelium in situ.", Exp Eye Res, vol. 129, pp. 1-4, 2014 Dec.
McKay, B. S., N. R. Congrove, A. A. Johnson, M. W Dismuke, T. J. Bowen, and D. W Stamer, "A role for myocilin in receptor-mediated endocytosis.", PLoS One, vol. 8, issue 12, pp. e82301, 2013. PMCID: PMC3867354
Falk, T., N. R. Congrove, S. Zhang, A. D. McCourt, S. J. Sherman, and B. S. McKay, "PEDF and VEGF-A output from human retinal pigment epithelial cells grown on novel microcarriers.", J Biomed Biotechnol, vol. 2012, pp. 278932, 2012. PMCID: PMC3323925
Bakall, B., R. A. Radu, J. B. Stanton, J. M. Burke, B. S. McKay, C. Wadelius, R. F. Mullins, E. M. Stone, G. H. Travis, and A. D. Marmorstein, "Enhanced accumulation of A2E in individuals homozygous or heterozygous for mutations in BEST1 (VMD2).", Exp Eye Res, vol. 85, issue 1, pp. 34-43, 2007 Jul. PMID: 17477921
Yu, L., U. Kelly, J. N. Ebright, G. Malek, P. Saloupis, D. W. Rickman, B. S. McKay, V. Y. Arshavsky, and C. Bowes Rickman, "Oxidative stress-induced expression and modulation of Phosphatase of Regenerating Liver-1 (PRL-1) in mammalian retina.", Biochim Biophys Acta, vol. 1773, issue 9, pp. 1473-82, 2007 Sep. PMCID: PMC2118714 PMID: 17673310
Rak, D. J., K. M. Hardy, G. J. Jaffe, and B. S. McKay, "Ca++-switch induction of RPE differentiation.", Exp Eye Res, vol. 82, issue 4, pp. 648-56, 2006 Apr. PMID: 16289163
Conley, S. M., B. S. McKay, J. A Gandolfi, and D. W Stamer, "Alterations in human trabecular meshwork cell homeostasis by selenium.", Exp Eye Res, vol. 82, issue 4, pp. 637-47, 2006 Apr. PMID: 16289047
McKay, B. S., B. Goodman, T. Falk, and S. J. Sherman, "Retinal pigment epithelial cell transplantation could provide trophic support in Parkinson's disease: results from an in vitro model system.", Exp Neurol, vol. 201, issue 1, pp. 234-43, 2006 Sep. PMID: 16764861
Stamer, W. D., K. M. Perkumas, E. A. Hoffman, B. C. Roberts, D. L. Epstein, and B. S. McKay, "Coiled-coil targeting of myocilin to intracellular membranes.", Exp Eye Res, vol. 83, issue 6, pp. 1386-95, 2006 Dec. PMID: 16973161
McLaughlin, P. J., Q. Chen, M. Horiguchi, B. C. Starcher, B. J Stanton, T. J. Broekelmann, A. D. Marmorstein, B. McKay, R. Mecham, T. Nakamura, et al., "Targeted disruption of fibulin-4 abolishes elastogenesis and causes perinatal lethality in mice.", Mol Cell Biol, vol. 26, issue 5, pp. 1700-9, 2006 Mar. PMCID: PMC1430262 PMID: 16478991
Hoffman, E. A., S. M. Conley, D. W Stamer, and B. S. McKay, "Barriers to productive transfection of trabecular meshwork cells.", Mol Vis, vol. 11, pp. 869-75, 2005 Oct 26. PMID: 16270026
Hardy, K. M., E. A. Hoffman, P. Gonzalez, B. S. McKay, and D. W Stamer, "Extracellular trafficking of myocilin in human trabecular meshwork cells.", J Biol Chem, vol. 280, issue 32, pp. 28917-26, 2005 Aug 12. PMID: 15944158
Yang, P., B. S. McKay, J. B. Allen, and G. J. Jaffe, "Effect of NF-kappa B inhibition on TNF-alpha-induced apoptosis in human RPE cells.", Invest Ophthalmol Vis Sci, vol. 45, issue 7, pp. 2438-46, 2004 Jul. PMID: 15223828
Yang, P., B. S. McKay, J. B. Allen, W. L. Roberts, and G. J. Jaffe, "Effect of mutant IkappaB on cytokine-induced activation of NF-kappaB in cultured human RPE cells.", Invest Ophthalmol Vis Sci, vol. 44, issue 3, pp. 1339-47, 2003 Mar. PMID: 12601067