Brian S. McKay

Brian S. McKay, PhD

Professor, Ophthalmology and Vision Science

Professor, Physiology

Documents

Links

Dr. Brian S. McKay received his Bachelor’s degree in biology from University of Wisconsin in Milwaukee then completed his PhD at the Medical College of Wisconsin where he studied cell biology related to retinal diseases. Dr. McKay conducted his postdoctoral training in protein chemistry at The Scripps Research Institute in San Diego, CA. Upon finishing his training, Dr. McKay joined the faculty at Duke University in Durham, NC, where he developed his laboratory around projects addressing the biology of age-related macular degeneration (AMD). Dr. McKay conducts basic research towards understanding retinal degenerations and the molecular origins of glaucoma, asking the key questions necessary for successful development of cell based therapies. His collaborations with the vitreoretinal surgical staff are central to the projects success. Research is conducted in RPE transplantation methods for AMD therapy, and protein expression in glaucoma. In collaboration with W. Daniel Stamer, PhD, he is examining the structure and function of the myocilin to determine why the specific trait of glaucomatous disease is passed on through a nearly ubiquitous protein.

American Journal of Medicine: Mining Retrospective Data for Virtual Prospective Drug Repurposing: L-DOPA and Age-related Macular Degeneration
UA News: Prevention Of Macular Degeneration Seen As Possible

Degrees

PhD, Medical College of Wisconsin, 1995

Publications

McKay, Brian S. Pigmentation and vision: is GPR143 in control? J Neurosci Res. 2019;97(1):77-87. doi:10.1002/jnr.24246

Nguyen, Thuy-Vi V, Hayes, Megan, McKay, Brian S, et al. Alzheimer’s associated amyloid and tau deposition co-localizes with a homeostatic myelin repair pathway in two mouse models of post-stroke mixed dementia. Acta Neuropathol Commun. 2018;6(1):100. doi:10.1186/s40478-018-0603-4

Chung, Amanda G, McKay, Brian S, Frye, Jennifer B, et al. Liquefaction of the Brain following Stroke Shares a Similar Molecular and Morphological Profile with Atherosclerosis and Mediates Secondary Neurodegeneration in an Osteopontin-Dependent Mechanism. eNeuro. 2018;5(5). doi:10.1523/ENEURO.0076-18.2018

McKay, B S, Allingham, R R, Stamer, W D. Is there a final common pathway in POAG? In: Glaucoma Research and Clinical Advances: 2018 to 2020 - Google Books [Internet]. Kugler Publications; 2018:99-110.

Brilliant, Murray H, McKay, Brian S, Vaziri, Kamyar, et al. Mining retrospective data for virtual prospective drug repurposing: L-DOPA and age-related macular degeneration. Am J Med. 2016;129(3):292-8. doi:10.1016/j.amjmed.2015.10.015

McKay, Brian S, Schwartz, Stephen G. Pigmentation and macular degeneration: is there a role for GPR143? J Ocul Pharmacol Ther. 2016;32(1):3-4. doi:10.1089/jop.2016.29007.bsm

Locke, Christina J, Congrove, Nicole R, Dismuke, W Michael, Bowen, Trent J, Stamer, W Daniel, McKay, Brian S. Controlled exosome release from the retinal pigment epithelium in situ. Exp Eye Res. 2014;129:1-4. doi:10.1016/j.exer.2014.10.010

Summers, C Gail, Connett, John E, McKay, Brian S, et al. Does levodopa improve vision in albinism? Results of a randomized, controlled clinical trial. Clin Exp Ophthalmol. 2014;42(8):713-21. doi:10.1111/ceo.12325

McKay, Brian S, Congrove, Nicole R, Johnson, Adiv A, Dismuke, W Michael, Bowen, Trent J, Stamer, W Daniel. A role for myocilin in receptor-mediated endocytosis. PLoS One. 2013;8(12):e82301. doi:10.1371/journal.pone.0082301

Dismuke, W Michael, McKay, Brian S, Stamer, W Daniel. Myocilin, a component of a membrane-associated protein complex driven by a homologous Q-SNARE domain. Biochemistry. 2012;51(17):3606-13. doi:10.1021/bi300073r

Falk, Torsten, Congrove, Nicole R, Zhang, Shiling, McCourt, Alexander D, Sherman, Scott J, McKay, Brian S. PEDF and VEGF-A output from human retinal pigment epithelial cells grown on novel microcarriers. J Biomed Biotechnol. 2012;2012:278932. doi:10.1155/2012/278932

Lopez, Vanessa M, Decatur, Christina L, Stamer, W Daniel, Lynch, Ronald M, McKay, Brian S. L-DOPA is an endogenous ligand for OA1. PLoS Biol. 2008;6(9):e236. doi:10.1371/journal.pbio.0060236

Yu, Ling, Kelly, Una, Ebright, Jessica N, et al. Oxidative stress-induced expression and modulation of Phosphatase of Regenerating Liver-1 (PRL-1) in mammalian retina. Biochim Biophys Acta. 2007;1773(9):1473-82. doi:10.1016/j.bbamcr.2007.06.005

Bakall, B, Radu, R A, McKay, B S, et al. Enhanced accumulation of A2E in individuals homozygous or heterozygous for mutations in BEST1 (VMD2). Exp Eye Res. 2007;85(1):34-43. doi:10.1016/j.exer.2007.02.018

Perkumas, K M, Hoffman, E A, McKay, B S, Allingham, R R, Stamer, W D. Myocilin-associated exosomes in human ocular samples. Exp Eye Res. 2007;84(1):209-12. doi:10.1016/j.exer.2006.09.020

Stamer, W D, Perkumas, K M, Hoffman, E A, Roberts, B C, Epstein, D L, McKay, B S. Coiled-coil targeting of myocilin to intracellular membranes. Exp Eye Res. 2006;83(6):1386-95. doi:10.1016/j.exer.2006.07.018

McKay, Brian S, Goodman, Brooke, Falk, Torsten, Sherman, Scott J. Retinal pigment epithelial cell transplantation could provide trophic support in Parkinson’s disease: results from an in vitro model system. Exp Neurol. 2006;201(1):234-43. doi:10.1016/j.expneurol.2006.04.016

Conley, Shannon M, McKay, Brian S, Gandolfi, A Jay, Stamer, W Daniel. Alterations in human trabecular meshwork cell homeostasis by selenium. Exp Eye Res. 2006;82(4):637-47. doi:10.1016/j.exer.2005.08.024

Rak, Daniel J, Hardy, Katherine M, Jaffe, Glenn J, McKay, Brian S. Ca++-switch induction of RPE differentiation. Exp Eye Res. 2006;82(4):648-56. doi:10.1016/j.exer.2005.09.002

McLaughlin, Precious J, Chen, Qiuyun, Horiguchi, Masahito, et al. Targeted disruption of fibulin-4 abolishes elastogenesis and causes perinatal lethality in mice. Mol Cell Biol. 2006;26(5):1700-9. doi:10.1128/MCB.26.5.1700-1709.2006

Hoffman, Emely A, Conley, Shannon M, Stamer, W Daniel, McKay, Brian S. Barriers to productive transfection of trabecular meshwork cells. Mol Vis. 2005;11:869-75.

Hardy, Katharine M, Hoffman, Emely A, Gonzalez, Pedro, McKay, Brian S, Stamer, W Daniel. Extracellular trafficking of myocilin in human trabecular meshwork cells. J Biol Chem. 2005;280(32):28917-26. doi:10.1074/jbc.M504803200

Yang, Ping, McKay, Brian S, Allen, Janice B, Jaffe, Glenn J. Effect of NF-kappa B inhibition on TNF-alpha-induced apoptosis in human RPE cells. Invest Ophthalmol Vis Sci. 2004;45(7):2438-46.

Stamer, W Daniel, Bok, Dean, Hu, Jane, Jaffe, Glenn J, McKay, Brian S. Aquaporin-1 channels in human retinal pigment epithelium: role in transepithelial water movement. Invest Ophthalmol Vis Sci. 2003;44(6):2803-8.

Yang, Ping, McKay, Brian S, Allen, Janice B, Roberts, Wendy L, Jaffe, Glenn J. Effect of mutant IkappaB on cytokine-induced activation of NF-kappaB in cultured human RPE cells. Invest Ophthalmol Vis Sci. 2003;44(3):1339-47.