Brian S. McKay, PhD

Professor, Ophthalmology and Vision Science
Professor, Physiology
Degrees: 
PhD, Medical College of Wisconsin, 1995
Research Interests: 

Dr. Brian S. McKay received his Bachelor’s degree in biology from University of Wisconsin in Milwaukee then completed his PhD at the Medical College of Wisconsin where he studied cell biology related to retinal diseases. Dr. McKay conducted his postdoctoral training in protein chemistry at The Scripps Research Institute in San Diego, CA. Upon finishing his training, Dr. McKay joined the faculty at Duke University in Durham, NC, where he developed his laboratory around projects addressing the biology of age-related macular degeneration (AMD). Dr. McKay conducts basic research towards understanding retinal degenerations and the molecular origins of glaucoma, asking the key questions necessary for successful development of cell based therapies. His collaborations with the vitreoretinal surgical staff are central to the projects success. Research is conducted in RPE transplantation methods for AMD therapy, and protein expression in glaucoma. In collaboration with W. Daniel Stamer, PhD, he is examining the structure and function of the myocilin to determine why the specific trait of glaucomatous disease is passed on through a nearly ubiquitous protein.

Publications

2003

Yang, P., B. S. McKay, J. B. Allen, W. L. Roberts, and G. J. Jaffe, "Effect of mutant IkappaB on cytokine-induced activation of NF-kappaB in cultured human RPE cells.", Invest Ophthalmol Vis Sci, vol. 44, issue 3, pp. 1339-47, 2003 Mar. PMID: 12601067

1997

McKay, B. S., and J. M. Burke, "Cell association increases RPE outgrowth from primary explant.", Curr Eye Res, vol. 16, issue 9, pp. 891-9, 1997 Sep. PMID: 9288450
McKay, B. S., P. E. Irving, C. M. Skumatz, and J. M. Burke, "Cell-cell adhesion molecules and the development of an epithelial phenotype in cultured human retinal pigment epithelial cells.", Exp Eye Res, vol. 65, issue 5, pp. 661-71, 1997 Nov. PMID: 9367646

1996

McKay, B. S., D. S. Annis, S. Honda, D. Christie, and T. J. Kunicki, "Molecular requirements for assembly and function of a minimized human integrin alphaIIbbeta3.", J Biol Chem, vol. 271, issue 48, pp. 30544-7, 1996 Nov 29. PMID: 8940024
Burke, J. M., C. M. Skumatz, P. E. Irving, and B. S. McKay, "Phenotypic heterogeneity of retinal pigment epithelial cells in vitro and in situ.", Exp Eye Res, vol. 62, issue 1, pp. 63-73, 1996 Jan. PMID: 8674514

1994

McKay, B. S., and J. M. Burke, "Separation of phenotypically distinct subpopulations of cultured human retinal pigment epithelial cells.", Exp Cell Res, vol. 213, issue 1, pp. 85-92, 1994 Jul. PMID: 7517370
Nash, R. W., B. S. McKay, and J. M. Burke, "The response of cultured human retinal pigment epithelium to hypoxia: a comparison to other cell types.", Invest Ophthalmol Vis Sci, vol. 35, issue 6, pp. 2850-6, 1994 May. PMID: 8188480

1993

Burke, J. M., and B. S. McKay, "In vitro aging of bovine and human retinal pigment epithelium: number and activity of the Na/K ATPase pump.", Exp Eye Res, vol. 57, issue 1, pp. 51-7, 1993 Jul. PMID: 8405172

1992

Arrindell, E. L., B. S. McKay, G. J. Jaffe, and J. M. Burke, "Modulation of potassium transport in cultured retinal pigment epithelium and retinal glial cells by serum and epidermal growth factor.", Exp Cell Res, vol. 203, issue 1, pp. 192-7, 1992 Nov. PMID: 1330655
Murray, T. G., G. J. Jaffe, B. S. McKay, D. P. Han, J. M. Burke, and G. W. Abrams, "Collagen shield delivery of tissue plasminogen activator: functional and pharmacokinetic studies of anterior segment delivery.", Refract Corneal Surg, vol. 8, issue 1, pp. 44-8; discussion 48-53, 1992 Jan-Feb. PMID: 1554639

1991

Burke, J. M., B. S. McKay, and G. J. Jaffe, "Retinal pigment epithelial cells of the posterior pole have fewer Na/K adenosine triphosphatase pumps than peripheral cells.", Invest Ophthalmol Vis Sci, vol. 32, issue 7, pp. 2042-6, 1991 Jun. PMID: 1647375

1988

Jaffe, G. J., G. D. Green, B. S. McKay, A. Hartz, and G. A. Williams, "Intravitreal clearance of tissue plasminogen activator in the rabbit.", Arch Ophthalmol, vol. 106, issue 7, pp. 969-72, 1988 Jul. PMID: 3134000

Pages